Table of Contents


The present issue of the Newsletter continues the theme of exploring societal and/or scientific implications of hormesis ASSUMING it exists and displays a stimulatory range of up to 10-fold, and a maximum stimulatory response of approximately 40-60% above the control within approximately 4-5-fold of the No Observed Adverse Effect Level (NOAEL) (Calabrese and Baldwin, 1997, 1997a) as represented in Figure 1.

Various experts were invited to assess whether such a phenomenon, if it were to exist, would be important for society to carefully consider. Thus, even though a person agreed to contribute should not be assumed that they would necessarily be supportive of the hormesis hypothesis per se.


Calabrese, E.J., and Baldwin, L.A. (1997). A quantitatively-based methodology for the evaluation of chemical hormesis. Hum. Ecolog. Risk Assmnt., 3(4):545-554.

Calabrese, E.J., and Baldwin, L.A. (1997a). The dose determines the stimulation (and poison): development of a chemical hormesis database. International. J. Toxicol., 16:545-559. Implications of the Hormesis Hypothesis for Risk Perception and Communication