Vol. 7, No. 2, November 1998
Biologically-Based Modeling of U-Shaped Carcinogen Responses
CONTENTS
1. INTRODUCTION
2. INVITED PAPERS ON U-SHAPED CARCINOGEN RESPONSES
A. Mechanistic Modeling of Rodent Liver Tumor Promotion at Low Levels of Exposure: An Example Related to Dose-Response Relationships for 2,3,7,8-Tetrachlorodibenzo-p-dioxin - Andersen, M.E. and Conolly, R.B.
B. Mechanistic Model Predicts a U-Shaped Relation of Radon Exposure to Lung Cancer Risk Reflected in Combined Occupational and U.S. Residential Data - Bogen, K.T.
C. A Cancer Risk Model with Adaptive Repair - Downs, T and Frankowski, R.
3. RESPONSE TO INVITED PAPERS BY AUTHORS
A. Review of the three papers in the BELLE Newsletter - Andersen, M.E.
B. Bogen's Comments on Papers by Andersen and Conolly and by Downs and Frankowski - Bogen, K.T.
C. Down's and Frankowski's Comments on Papers by Andersen and Conolly and Bogen - Downs, T. and Frankowski, R.
4. INVITED REVIEWER COMMENTS ON THE PAPERS BY ANDERSEN AND CONOLLY, BOGEN, AND DOWNS AND FRANKOWSKI
A. Comments on Papers on U-Shaped Dose-Response Relationships for Carcinogens - Moolgavkar, S.H.
B. U-Shaped Dose-Response Curves for Carcinogens - Portier, C.J. and Ye, F.
C. Responses to the Reports of Andersen, Bogen, and Downs - Hoel, D.G.
5. FINAL THOUGHTS OF THE INVITED PAPER AUTHORS
A. Bogen's Responses to Reviewer Comments
B. Andersen's Responses to Reviewer Comments